Under inflammasome related pyroptotic stress, caspase-1 and gasdermin D promote mtDNA escape into the cytosol, then drive intraluminal vesicle formation that enables mtDNA loading into intraluminal vesicles (ILVs) and release via exosomes
In FXR knockout mice, TMAO modulates hepatic bile acid/cholesterol transporter and synthase mRNA expression, reducing bile acid synthesis and cholesterol accumulation (Miyata et al., 2024)
Wynendaele, E., De Spiegeleer, B., Gevaert, B., Janssens, Y., Suleman, S., Cattoor, S., Saunders, J
Vitamin C, selenium, coenzyme Q10, and alpha-lipoic acid are all antioxidant supporters
Ron, D., Napolitano, E